Jeffrey Patton, PhD:
Associate Professor
Postdoctoral Fellowships:
Worcester Foundation for Experimental Biology, Shrewsbury, MA
Ph.D. University of North Carolina at Chapel Hill

Contact Information:
Office: (803) 216-3417
Fax: (803) 216-3428

Research Focus

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After transcription, all RNAs, whether they are transfer tRNAs (tRNAs), messenger RNAs (mRNAs), ribosomal RNAs (rRNAs) or small nuclear RNAs (snRNAs), are put through a series of processing steps. We are interested in discovering new protein factors that are involved in the metabolism of small stable RNAs such as tRNAs and snRNAs. These RNAs are instrumental in essential cellular processes such as protein synthesis and mRNA splicing. We are particularly interested in understanding the formation and function of nucleotide modifications in these RNAs, with an emphasis on the formation of pseudouridine, an isomer of uridine. We have begun to use Caenorhabditis elegans as a model system to define the roles of splicing and modification factors prior to investigating the role of their homologues in mammals.