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Pathology Microbiology & Immunology
Columbia, SC 29208
(803) 733-3275
Fax: (803) 733-1515
E-mail: smartin@gw.med.sc.edu
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Dr Jeffrey Patton
Associate Professor
Pathology, Microbiology & Immunology
USC School of Medicine
Columbia, SC 29208
Ph.D.
University of North Carolina at Chapel Hill
Post-doctoral Fellowships
Worcester Foundation for Experimental Biology,
Shrewsbury, MA
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Contact Information:
Office: (803) 733-3399
Fax: (803) 733-3192
E-mail: patton@med.sc.edu
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Research Interests
Search PubMed for publications by Dr Jeffrey Patton
After transcription, all RNAs, whether they are transfer tRNAs (tRNAs), messenger RNAs (mRNAs), ribosomal RNAs (rRNAs) or small nuclear RNAs (snRNAs), are put through a series of processing steps. We are interested in discovering new protein factors that are involved in the metabolism of small stable RNAs such as tRNAs and snRNAs. These RNAs are instrumental in essential cellular processes such as protein synthesis and mRNA splicing. We are particularly interested in understanding the formation and function of nucleotide modifications in these RNAs, with an emphasis on the formation of pseudouridine, an isomer of uridine. We have begun to use Caenorhabditis elegans as a model system to define the roles of splicing and modification factors prior to investigating the role of their homologues in mammals.
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