Dr Kevin Carnevale
Pathology Course Director
Clinical Assistant Professor
MD:Albert Einstein College of Medicine, Bronx, NY
Anatomical Pathology Residency: Columbia Presbyterian, NY, NY
Clinical Pathology Residency: Albert Einstein College of Medicine
Montefiore Medical Center, Bronx, NY
Postdoctoral: Cell Biology, Cleveland Clinic Foundation, Cleveland, OH

Research Interests

The complications of atherosclerosis such as heart attack and stroke are currently the number one and three causes of death in the US respectively. Balloon angioplasty with or without stent placement is the treatment of choice for coronary and peripheral vascular procedures. Within several months to a year one third to half of all patients develop restenosis leading to secondary procedures. Restenosis is due to the vessels response to injury combined with the body’s immune response. It is not the progression of the underlying atherosclerotic disease. The smooth muscle cells migrate from the muscular layer of the artery to the intima where they proliferate. If the smooth muscle migration could be inhibited, restenosis may be limited or possibly arrested. It is vitally important to understand the key regulators in the pathway affecting smooth muscle migration. Smooth muscle migration is also essential in the pathogenesis of atherosclerosis, transplant vasculopathy, and restenosis of bypass grafts.

The objective of our studies is to understand the role of phospholipase during restenosis. We have previously established the both cytosolic phospholipase A2 (cPLA2) and calcium independent phospholipase A2 (iPLA2) are essential for monocytes migration to monocytes chemoattractant protein 1 (also known as CCL2) both in vitro and in vivo. We are performing studies looking at smooth muscle migration and proliferation in cells that have been either inhibited or deficient in cytosolic phospholipase A2 (cPLA2). We hypothesize that this enzyme is a key component in the chemotaxis of macrophages which drives the inflammatory process in restenosis. Further experiments will measure the amount of macrophage inflammation the affects on smooth muscle cells and intimal hyperplasia during restenosis in the femoral artery of mice deficient in cPLA2. We are also doing proteomics to investigating the proteins expressed during different time points in restenosed arteries using a femoral cuff model and comparing it to the normal femoral arteries. We are trying to identify key inflammatory

Recent Publications

• Mishra RS, Carnevale KA, Cathcart MK. iPLA2{beta}: front and center in human monocyte chemotaxis to MCP-1. J Exp Med. 2008 Feb 18;205(2): 347-59.
• Yazici I, Carnevale K, Klimczak A, Siemionow M. A new rat model of maxilla allotransplantation. Ann Plast Surg. Mar;58(3): 338-44, 2007.
• Klimczak A, Agaogln G, Carnevale KA, Siemionow M. Applications of Bilateral Vascularized Femoral Bone Marrow Transplantion for Chimerism Induction Across the Major Histocompatibility (MHC) Barrier, Part II. Ann Plastic Surg 57(4): 422-30, 2006.
• Agaogln G, Carnevale KA, Zins JE, Siemionow M. Bilateral Vascularized Femoral Bone Transplant: A New Model of Vascularized Bone Marrow Transplantation in Rats, Part I. Ann Plastic Surg 56(6): 658-64, 2006.
• Carnevale KA, Ouriel K, Gabriel Y, Clair D, Bena JF, Silva MB, Sarac TP, Biologic Coating for Arterial Stents – The Next Evolutionary Change in Stents. J Endovasc Ther 13(2): 164-74, 2006.
• Sarac T, Carnevale KA, Smedira N, Tanquilut E, Augustinos P, Patel A, Naska T, Clair D, Ouriel K, In Vivo and Mechanical Properties of Peritoneum/Fascia as a Novel Arterial Substitute. J Vasc Surg 41(3): 490-97, 2005.
• Xiaoxian Z, Carnevale KA, Cathcart MK; Human Monocytes Use Rac 1, Not Rac 2, In the NADPH Oxidase Complex. J Biol Chem 278(42): 40788-40792, 2003.
• Carnevale KA and Cathcart MK; Protein Kinase C Beta is Required for Human Monocyte Chemotaxis to Monocyte Chemoattractant Protein 1. J Biol Chem 278(28): 25317-25322, 2003.
• Gurunluoglu R, Dogan T, Carnevale K; An 18-year-old Man with Swelling in his Left Thumb. Cleveland Clinic J Med 70(3): 192-200, 2003.
• Carnevale KA and Cathcart MK; Calcium Independent Phospholipase A2 is Required for Human Monocyte Chemotaxis to Monocyte Chemoattractant Protein 1. J. Immunol, 167(6): 3414-3421, 2001.